Filed under: Genetic Testing, Preparedness, Science, Science Fiction, Synesthesia, Titan, Writing stuff
I’ve written previously about the emergence of consciousness and the role that the biochemical stew in our heads plays in awareness and cognition. But let’s get a little more basic in our analysis. Let’s consider fire. No, not the slow fire of chemical reactions in our bodies, but actual burning of wood, and the role that it may have played in the development of human intelligence.
* * * * * * *
The Greek myth of Prometheus bringing the holy fire of Zeus to mankind, and thereby enabling civilization, has usually been understood as being an explanation of the role which technology plays in human development. After all, fire allows humans to control our environment, from living in colder climates to clearing land for farming to metallurgy. And, of course, to cook food, making a wider range of nutrients available.
But what if fire made human thought itself possible?
Cooking and Cognition: How Humans Got So Smart
After two tremendous growth spurts — one in size, followed by an even more important one in cognitive ability — the human brain is now a lot like a teenage boy.
It consumes huge amounts of calories, is rather temperamental and, when harnessed just right, exhibits incredible prowess. The brain’s roaring metabolism, possibly stimulated by early man’s invention of cooking, may be the main factor behind our most critical cognitive leap, new research suggests.
OK, that article is a little light on actual information. So I went to check the research paper. It’s a bit thick, but the basic idea was to study the rise of human cognition via two methods:
In this study, we attempted to identify molecular mechanisms involved in the evolution of human-specific cognitive abilities by combining biological data from two research directions: evolutionary and medical. Firstly, we identify the molecular changes that took place on the human evolutionary lineage, presumably due to positive selection. Secondly, we consider molecular changes observed in schizophrenia, a psychiatric disorder believed to affect such human cognitive functions as the capacity for complex social relations and language [6–12]. Combining the two datasets, we test the following prediction: if a cognitive disorder, such as schizophrenia, affects recently evolved biological processes underlying human-specific cognitive abilities, we anticipate finding a significant overlap between the recent evolutionary and the pathological changes. Furthermore, if such significant overlap is observed, the overlapping biological processes may provide insights into molecular changes important for the evolution and maintenance of human-specific cognitive abilities.
Got that? First, you determine the differences due to evolution (specifically as seen in DNA/mRNA divergence between us and chimpanzees), then you see where the brains of people who have schizophrenia are different from ‘normal’ brains. That can give you some indications of how cognition works, since schizophrenia is known to primarily impact cognition.
What did the researchers find?
In order to select human-specific evolutionary changes, we used the published list of 22 biological processes showing evidence of positive selection in terms of their mRNA expression levels in brain during recent human evolution [13]. Next, we tested whether expression of genes contained in these functional categories is altered in schizophrenia to a greater extent than expected by chance. To do this, we ranked 16,815 genes expressed in brain in order of probability of differential expression in schizophrenia, using data from a meta-analysis of 105 individuals profiled on 4 different microarray platforms in 6 independent studies [14]. We found that 6 of the 22 positively selected biological processes are significantly enriched in genes differentially expressed in schizophrenia (Wilcoxon rank sum test, p < 0.03, false discovery rate (FDR) = 11%), while only 0.7 would be expected to show such an enrichment by chance (Figure 1; Table S2 in Additional data file 1; Materials and methods). Strikingly, all six of these biological processes are related to energy metabolism. This is highly unexpected, given that there were only 7 biological processes containing genes involved in energy metabolism among the 22 positively selected categories (Figure 1; Table S2 in Additional data file 1). The mRNA expression changes observed in schizophrenia appear to be distributed approximately equally in respect to the direction of change, pointing towards a general dysregulation of these processes in the disease rather than a coordinated change (Table S3 in Additional data file 1).
Simply put: it’s metabolism. The brain eats up a lot of energy, about 20% of all the energy you take in as food. That’s a lot – for chimps the number is about 13%, and for other vertebrates it runs 2 – 8%. The conclusion:
In this study we find a disproportionately large overlap between processes that have changed during human evolution and biological processes affected in schizophrenia. Genes relating to energy metabolism are particularly implicated for both the evolution and maintenance of human-specific cognitive abilities.
Using 1H NMR spectroscopy, we find evidence that metabolites significantly altered in schizophrenia have changed more on the human lineage than those that are unaltered. Furthermore, genes related to the significantly altered metabolites show greater sequence and mRNA expression divergence between humans and chimpanzees, as well as indications of positive selection in humans, compared to genes related to the unaltered metabolites.
Taken together, these findings indicate that changes in human brain metabolism may have been an important step in the evolution of human cognitive abilities. Our results are consistent with the theory that schizophrenia is a costly by-product of human brain evolution [11,37].
When did this take place? From the LiveScience article first cited:
The extra calories may not have come from more food, but rather from the emergence of pre-historic “Iron Chefs;” the first hearths also arose about 200,000 years ago.
In most animals, the gut needs a lot of energy to grind out nourishment from food sources. But cooking, by breaking down fibers and making nutrients more readily available, is a way of processing food outside the body. Eating (mostly) cooked meals would have lessened the energy needs of our digestion systems, Khaitovich explained, thereby freeing up calories for our brains.
* * * * * * *
In Communion of Dreams, I posit the use of “auggies” – drugs designed to maximize the utilization of neurotransmitters in the brain. When combined with increased sensory information thanks to technology, an artificial kind of synesthesia occures, allowing for insights (artistic, cognitive) otherwise beyond human ability. But it is a cheat – you ‘burn up’ the available neurotransmitters quickly, accelerating brain function, but are left then less capable for a period of days after as the body replenishes. This is by and large a metabolic function – the same way an athlete can burn up energy stored in muscles in one brief period, but then needs time to recover.
I wrote this with an instinctive understanding of the mechanism involved – we’ve all experienced something akin to this phenomenon of pushing ourselves mentally for a short period, being tired and less able to think clearly afterwards. It’s a bit surprising to find that it may have literally been the same mechanism which lead to the rise of human intelligence to begin with.
And as for the alien artifact on Titan, which causes a similar phenomenon? Just coincidence that Prometheus was one of the Titans in Greek mythology.
No, really – just coincidence.
Jim Downey
*and yes, I realize that this isn’t quite what The Doors meant.
Filed under: 2nd Amendment, ACLU, Babylon 5, Civil Rights, Constitution, Daily Kos, Emergency, Failure, General Musings, Government, Guns, J. Michael Straczynski, JMS, Politics, Predictions, Preparedness, RKBA, Science Fiction, Society, Survival
There’s a line from a Babylon 5 episode (I’m a big fan of the series) which has always stuck with me. Several characters are discussing the political situation on Earth following the imposition of martial law. One character says that people love it – crime is down, things are calm, peaceful.
“Yeah, the peace of the gun,” replies another character.
And that, my friends, is what we have today, here in the US. Specifically, in one small city in Arkansas:
HELENA-WEST HELENA, Ark. – Officers armed with military rifles have been stopping and questioning passers-by in a neighborhood plagued by violence that’s been under a 24-hour curfew for a week.
On Tuesday, the Helena-West Helena City Council voted 9-0 to allow police to expand that program into any area of the city, despite a warning from a lawyer with the American Civil Liberties Union of Arkansas that the police stops were unconstitutional.
Police Chief Fred Fielder said the patrols have netted 32 arrests since they began last week in a 10-block neighborhood in this small town on the banks of the Mississippi River long troubled by poverty. The council said those living in the city want the random shootings and drug-fueled violence to stop, no matter what the cost.
“Now if somebody wants to sue us, they have an option to sue, but I’m fairly certain that a judge will see it the way the way the citizens see it here,” Mayor James Valley said. “The citizens deserve peace, that some infringement on constitutional rights is OK and we have not violated anything as far as the Constitution.”
From another source:
Controversial Curfew in Helena-West Helena
Mayor James Valley has given residents in one high-crime neighborhood two choices…. go home or go to jail.
Valley’s issued a mandatory curfew for Second Street and the surrounding blocks — a place he considers to be a “hot spot” for crime. The curfew applies to anyone of any age at any time of day.
* * *
“This turf belongs to taxpaying citizens, not to hustlers and drug dealers….We are going to pop them in the head,” Mayor Valley said.
* * *
The mayor only has the power to issue a 48 hour curfew – so he says when this one expires, he’ll issue another one, and another one.
Predictably, the ACLU is taking a rather dim view of this:
The ACLU has written a letter to Helena-West Helena Mayor James Valley protesting the curfew he imposed on a portion of the city. The mayor says he’s received the letter, but believes it’s intentions are misplaced.
* * *
Mayor James Valley says no constitutional rights have been violated — he says they’re doing what’s needed to clean up the streets.
No doubt. And he’s willing to be reasonable:
Helena-West Helena Curfew Changes
Leaders in Helena-West Helena have come up with a new plan after criticism by the ACLU of the mayor’s recent curfew on a particular part of town.
This past weekend, Mayor James Valley issued a mandatory curfew for Second Street and the surrounding blocks — a place he considers to be a “hot spot” for crime.
* * *
Valley’s curfew will remain in place for all minors, but adults will be allowed out if they can answer questions about their need to be outside their homes.
See, like I said – he’s being perfectly reasonable about this. You can leave your house. If you can explain to authorities why you need to do so.
How could anyone possibly object to this?
*sigh*
This is nothing more or less than the peace of the gun. This is the abrogation of civil liberties as a solution for incompetent governance. Of course people like it – let things get bad enough that they fear for their lives more than they value their liberties, and you can get people to do almost anything. Mayor Valley is just applying the same logic as he applied in mid July when he, well, here’s the news report:
Mayor Orders Dogs Released Into Forest
You’ve heard it before…..Arkansas animal shelters struggling to take care of unwanted dogs and cats. One mayor has decided the best way to fix the problem in his town is to set the animals free.
KARK visited the Helena-West Helena animal shelter back in January. Conditions were dirty and animals were in poor health.
Thursday, KARK learned the town’s mayor James Valley has taken the unconventional approach of releasing the animals into the wild. In a press release, the mayor says “we fed and watered them and took them to the St. Francis National Forest.”
Yeah, he just turned them loose.
Like I said, incompetence. Let things get so bad, and then you can take absurd steps.
Like imposing martial law.
Is this just a trial run for other cities? Other levels of government? Because you can be damned sure that there are power-hungry people watching this situation very closely, and drawing their own conclusions. If a small-town mayor can get away with it, why not a large city mayor? Or a governor? Or a president?
Jim Downey
(Cross posted to UTI and Daily Kos.)
Filed under: George Orwell, Government, Politics, Privacy, Publishing, Society, Writing stuff
Or maybe you don’t. My own knowledge of George Orwell was limited to his most popular novels (Animal Farm, Nineteen Eighty-Four) until graduate school, when I also delved into some of his essays. Any would-be writer, and almost anyone interested in political rhetoric, should be familiar with “Politics and the English Language”. His piece on “Why I Write” had a powerful impact on me, and I still find that this passage at the end resonates strongly:
All writers are vain, selfish, and lazy, and at the very bottom of their motives there lies a mystery. Writing a book is a horrible, exhausting struggle, like a long bout of some painful illness. One would never undertake such a thing if one were not driven on by some demon whom one can neither resist nor understand. For all one knows that demon is simply the same instinct that makes a baby squall for attention. And yet it is also true that one can write nothing readable unless one constantly struggles to efface one’s own personality. Good prose is like a windowpane. I cannot say with certainty which of my motives are the strongest, but I know which of them deserve to be followed. And looking back through my work, I see that it is invariably where I lacked a political purpose that I wrote lifeless books and was betrayed into purple passages, sentences without meaning, decorative adjectives and humbug generally.
Well, anyway, if you’ve enjoyed Orwell’s writing, you may also enjoy his diaries. The Orwell Prize has just started running entries from Orwell’s diaries 70 years ago, posting them day-to-day as a blog starting with the first entry dated August 9, 1938/2008. As stated on the blog:
From 9th August 2008, you will be able to gather your own impression of Orwell’s face from reading his most strongly individual piece of writing: his diaries. The Orwell Prize is delighted to announce that, to mark the 70th anniversary of the diaries, each diary entry will be published on this blog exactly seventy years after it was written, allowing you to follow Orwell’s recuperation in Morocco, his return to the UK, and his opinions on the descent of Europe into war in real time. The diaries end in 1942, three years into the conflict.
What impression of Orwell will emerge? From his domestic diaries (which start on 9th August), it may be a largely unknown Orwell, whose great curiosity is focused on plants, animals, woodwork, and – above all – how many eggs his chickens have laid. From his political diaries (from 7th September), it may be the Orwell whose political observations and critical thinking have enthralled and inspired generations since his death in 1950. Whether writing about the Spanish Civil War or sloe gin, geraniums or Germany, Orwell’s perceptive eye and rebellion against the ‘gramophone mind’ he so despised are obvious.
I’m looking forward to it, to seeing how this man’s mind understood the changing events of the world around him at a critical juncture. Maybe you will, as well.
Jim Downey
(Cross posted to Daily Kos.)
Jon walked to the edge of the pool. He heard a noise behind him, turned slowly to look at it.
From beside a large bush a pile of boulders shifted. The air shimmied, light danced, and a crouching figure emerged, covered in a fabric drape that tried to keep up with the changing surroundings. One hand pulled the drape to the side. Another was holding a very large sidearm.
Excerpt from Chapter 18 (page 258 of the .pdf) of Communion of Dreams. That’s my description of a military ‘stealth suit’ being used by one of the characters. Why do I mention it? Because:
WASHINGTON – Scientists say they are a step closer to developing materials that could render people and objects invisible.
Researchers have demonstrated for the first time they were able to cloak three-dimensional objects using artificially engineered materials that redirect light around the objects. Previously, they only have been able to cloak very thin two-dimensional objects.
The findings, by scientists at the University of California, Berkeley, led by Xiang Zhang, are to be released later this week in the journals Nature and Science.
The new work moves scientists a step closer to hiding people and objects from visible light, which could have broad applications, including military ones.
Wow. Another prediction coming true in my lifetime.
Jim Downey
Filed under: 2nd Amendment, Alzheimer's, Ballistics, Book Conservation, General Musings, Health, Hospice, Marketing, Predictions, Promotion, Publishing, Sleep, University of Missouri, Writing stuff, YouTube
I took some books back to Special Collections yesterday afternoon. As I was unpacking items, one of the staff members asked how I was doing.
“Pretty well. Been busy.”
She looked at me for a long moment. “You look – rested.”
* * * * * * *
On Wednesday, in response to a friend who asked what I had going on, I sent this email reply:
Need to do some blogging this morning, then get settled into the next batch of books for a client. Print out some invoices. Also need to track down some camera software and get it loaded onto this machine, and finish tweaking things here so I can shift over the last of the data from the old system and send it on its way. Need to work on learning some video editing, and start uploading clips from our ballistics testing project to YouTube. Then I can get going on creating the rest of the content for *that* website. Play with the dog. Should touch base with my collaborator on the Alz book, see where he is on some transcriptions he is working on. And then prep dinner. In other words, mostly routine. Yeah, I lead an odd life.
An odd life, indeed.
But here’s a taste of some of the documentation about the ballistics project that I have been working on:
That’s me wearing the blue flannel overshirt. Man, I’m heavy. I hope video of me now would look better.
* * * * * * *
The chaos continues. Yeah, we’re still in the process of completely re-arranging the house, and of seeing to the distribution of Martha Sr’s things. Looks like there’ll be an estate auction in our future sometime next month. But that’s good – it means that things are moving forward, heading towards some kind of resolution.
As mentioned in passing in the email cited above, I’ve been shifting over to a new computer system I got last week. My old system was starting to lose components, and was becoming increasingly incapable of doing things I need to be able to do. Well, hell, it was 7 years old, and was at least one iteration behind the cutting edge at the time I bought it. Thanks to the help of my good lady wife, this has been a relatively painless transition – though one which has still taken a lot of work and time to see through.
And one more complication, just to keep things interesting: My wife is moving her business practice home. This had been the tentative plan all along, once Martha Sr was gone, and for a variety of reasons it made sense to take this step now. She’ll be able to devote more of her energy to seeing to her mom’s estate, hastening that process. And she’s going to take on the task of shopping my book around agencies and publishers. Now that there have been over 10,000 downloads (actually, over 11,000 and moving towards 12,000), it would seem to be a good time to make a devoted push to getting the thing conventionally published, in spite of the problems in the industry. We’re hoping that she’ll be better able to weather the multiple rejections that it will take, and I’ll have more time and energy for working on the next book (and blogging, and the ballistics project, and – oh, yeah – earning money for a change).
* * * * * * *
She looked at me for a long moment. “You look – rested.”
“Thanks!”
It says something that with all I’ve been doing (as described above has been fairly typical, recently), I look more rested now than I have in years.
Actually, it says a lot.
Jim Downey
Filed under: Civil Rights, Constitution, Daily Kos, General Musings, Government, Guns, Politics, Society, Violence
Last week, in the investigation of a major drug distribution network, police staged a no-knock entry into a private residence. They seized over 30 pounds of marijuana. Two guard dogs who were a threat to the police had to be killed in the execution of the raid. Two people in the residence at the time were handcuffed at the scene and questioned as to their involvement in the crime.
Sound pretty straight forward? More or less standard procedure when police are investigating a large quantity of narcotics?
Well, how about this version of the story?
It now appears that the entire raid on Berwyn Heights, Maryland Mayor Cheye Calvo may have been illegal. Last week, police stormed Calvo’s home without knocking, shot and killed his two black labs, and questioned him and his mother-in-law at gunpoint over a delivered package of marijuana that police now concede may have been intended for someone else.
The Washington Post reports that the police didn’t even bother to get a no-knock warrant, which means the tactics they used were illegal:
A Prince George’s police spokesman said last week that a Sheriff’s Office SWAT team and county police narcotics officers were operating under such a [no-knock] warrant when they broke down the door of Berwyn Heights Mayor Cheye Calvo, shooting and killing his black Labrador retrievers.
But a review of the warrant indicates that police neither sought nor received permission from Circuit Court Judge Albert W. Northrup to enter without knocking. Northrup found probable cause to suspect that drugs might be in the house and granted police a standard search warrant.
“There’s nothing in the four corners of the warrant saying anything about the Calvos being a threat to law enforcement,” said Calvo’s attorney, Timothy Maloney. “This was a lawless act by law enforcement.”
Oh, a couple more things to fill in the blanks. One of the labs shot was running away from the police:
As the police came in, Calvo said, they shot his 7-year-old black Labrador retriever, Payton, near the front door and then his 4-year-old dog, Chase, also a black Lab, as the dog ran into a back room. Walking through his house yesterday, Calvo pointed out a bullet hole in the drywall where the younger dog had been shot.
The police were the ones who delivered the package:
Calvo’s home was raided after he brought a package addressed to his wife inside from his front porch. Police had been tracking the package since a dog sniffed the presence of drugs in Arizona. It was delivered to the house by police posing as deliverymen and left on the porch on the instruction of Calvo’s mother-in-law.
Police are required to provide a copy of any search warrant at the time the search is conducted. They got around to doing this several days later:
Another issue that could arise in court is whether officers provided Calvo a copy of the warrant at the time of the raid, as required by law. Maloney [attorney for Calvo] said they did not, even though a detective signed a sworn statement to the judge indicating that he had. Instead, the detective brought the warrant to Calvo several days later, Maloney said.
*Sigh*
Let’s recap: In the course of investigating a suspected drug distribution network known to be using false deliveries to private homes, police intercept one such package. Posing as delivery personnel, they take it to the home of Cheye Calvo. Where they are told to leave it on the porch. (Who the hell would leave an expected shipment of 32 pounds of pot sitting on the porch???) When Mayor Calvo gets home, he takes the package inside and sets it aside, leaving it unopened. A short time later, a SWAT team kicks in his door, and shoots his dogs, rather than having coordinated with local police to gain access to the suspect and home without the need to resort to violent tactics. Calvo and his MIL are handcuffed and interrogated at the premises for hours. No warrant authorizing the raid is produced until days after the event.
One more quote from the Washington Post story yesterday:
Were Calvo or his wife, Trinity Tomsic, to be charged in the case, the issue of the search could come up if prosecutors tried to introduce the box of marijuana as evidence. More likely, experts said, the issue could form the basis of a civil rights lawsuit filed by the family against the county in the incident.
No shit. The authorities responsible for this debacle are facing a huge lawsuit. And they’re damned lucky that the only bodies on the floor were dogs (as tragic as that itself is).
And consider for just a moment how this situation might have been reported differently were Calvo and his wife black or Hispanic, had they not lived in a nice middle-class home, had he not been well established and politically connected. Consider for just a moment if this situation had happened to you.
Jim Downey
(Cross posted to Daily Kos and UTI.)
I’m not a big fan of the Olympics, but Chris Cope has a good take on things. An American living in Cardiff (Wales, you twit, part of the UK), he has an interesting perspective. And he certainly is right here:
That said, the BBC is certainly giving it its best effort. We are promised wall-to-wall coverage via TV, radio, online and mobile phones. Huge television screens have been erected in a number of city centers across the country. And a terrifying animated kung-fu monkey has been unveiled to promote the event.
In Britain, we are required by law to pay $275 a year for the privilege of watching television. This is where our money goes.
I’m particularly amused by the kung-fu monkey, whose name is … Monkey. A two-minute cartoon of his traveling to the Bird’s Nest with a pig and strange water zombie has been airing with increasing frequency over the past few weeks. It is surreal every time I see it.
Surreal is right. Wow. You’ve gotta see that to believe it.
Jim Downey
(Hat tip to Alix. Cross posted to UTI.)
Filed under: BoingBoing, Climate Change, Cory Doctorow, Emergency, Flu, General Musings, Global Warming, Government, Heinlein, Pandemic, Plague, Predictions, Robert A. Heinlein, Science Fiction, Society, Space, tech, Tor.com, Weather, Writing stuff
Via BoingBoing, an interesting discussion over on Tor.com: The Dystopic Earths of Heinlein’s Juveniles. An excerpt:
It’s funny how it’s overpopulation and political unpleasantness that cause the problems, never ecological disaster. Maybe that wasn’t on the horizon at all in the fifties and early sixties? I suppose every age has its own disaster story. It’s nice how little they worry about nuclear war too, except in Space Cadet which is all nuclear threat, Venusians and pancakes. They don’t make them like that any more. Come to think it’s probably just as well.
* * *
No individual one of these would be particularly noticeable, especially as they’re just background, but sitting here adding them up doesn’t make a pretty picture. What’s with all these dystopias? How is it that we don’t see them that way? Is it really that the message is all about “Earth sucks, better get into space fast”? And if so, is that really a sensible message to be giving young people? Did Heinlein really mean it? And did we really buy into it?
Yeah, he meant it. And further, he was right.
No, I’m not really calling into question the premise of the piece – that Heinlein had something of a bias about population and governmental control. And I’m not saying that he was entirely correct in either his politics or his vision of the future.
But consider the biggest threat facing us: No, not Paris Hilton’s involvement in the presidential election, though a legitimate case can be made that this is indeed an indication of the end of the world. Rather, I mean global warming.
And why do we have global warming? Because of the environmental impact of human civilization. And why is this impact significant? Because of the size of the human population on this planet.
And what is the likely response to the coming changes? Increased governmental control.
[Mild spoilers ahead.]
For Communion of Dreams I killed off a significant portion of the human race as part of the ‘back story’. Why? Well, it served my purposes for the story. But also because I think that one way or another, we need to understand and accept that the size of our population is a major factor in all the other problems we face. Whether it is limitations caused by peak oil or some other resource running out, or the impact of ‘carbon footprints’, or urban sprawl, or food shortages, all of these problems have one common element: population pressure. We have too many people consuming too many resources and generating too much pollution. In fact, when I once again turn my writing the prequel to Communion, I may very well make this connection more explicit, and have the motivation of the people responsible for the fireflu based on this understanding.
So yeah, Heinlein was right. He may not have spelled out the end result (ecological disaster) per se, but he understood the dynamic at work, and what it would lead to. Just because things haven’t gotten as bad as they can get doesn’t mean that we’re not headed that direction. Our technology can only compensate for so long – already we see things breaking down at the margins, and the long term problems are very real. You can call it ‘dystopic’, but I’ll just call it our future.
Jim Downey
